EDUCATION

  • M.D. Degree University of Nuevo Leon School of Medicine, Monterrey, N.L., Mexico.
  • B.S. (Biology) Degree, College of Bachelors, Torreon, Coah., Mexico.

PROFESSIONAL EXPERIENCE

  • Director, Dr. Frank Arguello Cancer Clinic. Los Cabos, BCS. Mexico.
  • Section Head of Preclinical Research & Development, Department of Drug Discovery, Institute of Research Cesare Serono S.P.A., The Ares-Serono Group, Ardea-Rome, Italy.
  • Senior Investigator, Laboratory of Drug Discovery, Research and Development, Division of Cancer Treatment, Developmental Therapeutics Program, National Cancer Institute-FCRDC, National Institutes of Health, Frederick, MD.
  • Assistant Professor of Pediatrics and Oncology, Department of Pediatrics, Hematology/Oncology Division, and The Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY.
  • Senior Instructor of Pediatrics, Department of Pediatrics, Hematology/Oncology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY.
  • James P. Wilmot Instructor and Fellow of Pediatrics, Department of Pediatrics, Hematology/Oncology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY.
  • Research Associate, Department of Pediatrics, Hematology/ Oncology Division, University of Rochester School of Medicine and Dentistry, Rochester, NY.
  • Postdoctoral Fellow, Division of Medical Oncology, University of Connecticut Health Center, Farmington, CT.
  • Postdoctoral Fellow, Department of Pharmacology and Toxicology, Cancer Research Unit, University of Nuevo Leon, Monterrey, N.L., Mexico.
  • Intern, University Hospital “Jose E. Gonzalez,” University of Nuevo Leon, Monterrey, N.L., Mexico.

FRANK ARGUELLO 

CURRICULUM VITAE & SCIENTIFIC TRAJECTORY

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PUBLICATIONS

  • Arguello, F., Atavistic Metamorphosis: A New and Logical Explanation For The Origin And Biological Nature Of Cancer. With a discussion on a novel approach to treat cancer, 2011.
  • Jayaram HN, Yalowitz JA, Arguello F, Greene JF Jr.. Toxicity and efficacy of benzamide riboside in cancer chemotherapy (Review). Curr Med Chem. 7:787-792, 2002
  • Arguello, F., Alexander, M.A., Sterry, J.A., Tudor, G., Smith, E.M., Kalavar, N.T., Greene, J.F., Stinson, S.F., Koss, W., Morgan, D., Alvord, W.G., Klabansky, R.L., Markaverich, B.M., Sausville, E.A. The cyclin-dependent kinase inhibitor, flavopiridol, induces selective apoptosis of lymphoid cells in vivo, causes immunosuppression, and has the ability to produce complete regression of human leukemia and lymphoma xenografts. Blood, 91:2482-2490, 1998.
  • Greene, J.F., Morgan, C.D., Rao, A., Harris, A., Pennington, J.C., Smith, E.M., Arguello, F. Differentiation of amelanotic melanoma into pigmented histiocyte-like cells after diphtheria toxin treatment in vivo. Lab. Invest. Submitted.
  • Arguello, F., Alexander, M.A., Greene, J.F., Stinson, S.S., Smith, E.M., Kalavar, N.T., Alvord, W.G., Klabansky, R.L., Sausville, E.A. Preclinical evaluation of 9-chloro-2-methylelipticinium acetate alone and in combination with conventional anticancer drugs for the treatment of human brain tumor xenografts. J. Cancer Res. Clin. Oncol. 124:19-26, 1998.
  • Greene, J.F., Morgan, C.D., Rao, A., Amoss, M.S., Arguello, F. Regression by differentiation in the Sinclair swine model of cutaneous melanoma. Melanoma Res, 1997 7:471-477, 1997.
  • Arguello, F., Sterry, J.A., Zhao, Y.Z., Alexander, M.R.A., Shoemaker, R.H., Cohen, H.J. Two serologic markers to monitor the engraftment, growth and treatment response of human leukemias in severe combined immunodeficient mice. Blood, 87: 4325-4332, 1996.
  • Arguello, F., Cohen, H.J. Structural and microenvironmental bone marrow factors involved in the pathogenesis of bone metastasis. In: Orr, F.W. and Singh, G. (eds.), Mechanisms and Pathophysiology of Bone Metastasis. R.G. Landes, Co., Texas, 1996.
  • Eskenazi, A.E., Pinkas, J., Whithin, J.C., Arguello, F., Cohen, H.J., Frantz, C.N. The role of antioxidant enzymes in the induction of increased experimental metastasis by hydroxyurea. J. Natl. Cancer Inst. 85:711-721, 1993.
  • Arguello, F., Baggs, R.B., Harwell, S.E., Frantz, C.N., Cohen, H.J. Effect of IL-1 alfa on experimental bone marrow metastasis. Intl. J. Cancer 52:802-807, 1992.
  • Arguello, F., Furlanetto, R.W., Baggs, R.B., Harwell, S.E., Cohen, H.J., Frantz, C.N. Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes S1/S1d and W/Wv). Cancer Res. 52:2304-2309, 1992.
  • Arguello, F., Baggs, R.B., Duerst, E.R., Eskenazi, A., Frantz, C.N. Vascular anatomy and organ-specific tumor growth as critical factors in the development of metastases and their distribution among organs. Intl. J. Cancer. 48:583-590, 1991.
  • Arguello, F., Frantz, C.N., Baggs, R.B. Experimental bone and bone marrow metastasis in laboratory animals. J. National Cancer Inst. 82:1069, 1990.
  • Arguello, F., Baggs, R.B., Duerst, E.R., Johnstone, L., McQueen, K., Frantz, C.N. Pathogenesis of vertebral metastasis and epidural spinal cord compression. Cancer. 65:98-106, 1990.
  • Arguello, F., Baggs, R.B., Frantz, C.N. A murine model of experimental metastasis to bone and bone marrow. Cancer Res. 48: 6876-6881, 1988.

PRESENTATIONS

  • Arguello, F. The Athymic Nude Rate (rnu/rnu); Its Usefulness in Biomedical Research. Proc. III Regional Meeting in Biomedical Research, Monterrey, N.L., Mexico, 3:7, 1983.
  • Arguello, F., Ancer, R.J., Barbosa, R., Pineyro, P.A. Transplantation of Human Malignant Tumors in Nude Rate (rnu/rnu): A Biologic, Morphologic and Ultrastructural Study. Proc. XXVII National Congress of Pathological Anatomy, San Luis Potosi, SLP., Mexico, 27:60, 1984.
  • Arguello, F. Immune Mother-Fetus Relationship. Proc. Symposium on Maternal Fetal ISO Immunization, Gynecology and Obstetrics Society, Monterrey, N.L., Mexico, 6(2), 1985.
  • Arguello, F., Baggs, R.B., Frantz, C.N. Metastasis to Bone Marrow and Bone: An Experimental Murine Model. Proc. 79th Annual Meeting of the American Association for Cancer Research, 29: 272, 1988.
  • Arguello, F., Baggs, R.B., Frantz, C.N. Experimental Metastatic Disease of the Spine and Epidural Spinal Cord Compression in Mice. Proc. 25th Annual Meeting of the American Society of Clinical Oncology, 8:358, 1989.
  • Arguello, F., Baggs, R.B., Cramer, S.W., Frantz, C.N. Bone Metastasis: Process of Colonization and Destruction of Bone by Human and Murine Tumor Cells in Mice. Proc. 80th Annual Meeting of the American Association for Cancer Research, 30:357, 1989.
  • Arguello, F., Baggs, R.B., Frantz, C.N. Bone Marrow is a Fertile Soil for Cancer Metastasis: Studies of Systemic Intra-arterial Injection of Tumor Cells. March 7, 1989. Proc. International Symposium on Critical Determinants in Cancer Progression and Metastasis, 137(70), 1989.
  • Arguello, F., Eskenazi, A.E., Baggs, R.B., Frantz, C.N. The Role of Batson’s Vertebral Venous Plexus in the Development of Skeletal Metastasis. A Second Look. Proc. 1990 Annual Meeting of the American Society for Clinical Oncology, 9:217, 1990.
  • Arguello, F., Baggs, R.B., Johnstone, L., Frantz, C.N. Role of Bone Marrow Stroma in Bone Metastasis. Proc. 1990 Annual Meeting of the American Association for Cancer Research, 31:381, 1990.
  • Arguello, F., Baggs, R.B., Frantz, C.N. Incidence and Distribution of Metastasis in Mutant Mice with Cellular Defects in Bone Marrow (Genotypes S1/S1d and W/Wv). Proc. 1990 Lake Ontario Metastasis Group Meeting, Montreal, Quebec, Canada, 1:7, 1990.
  • Arguello, F., Sarma, K., Baggs, R.B., Frantz, C.N., Cohen, H.J. IL-1 Promotes the Establishment of Bone Metastasis. Proc. 1991 Annual Meeting of the American Association for Cancer Research, 32:370, 1991.
  • Arguello, F., Rubin, P., Baggs, R.B., Frantz, C.N., Cohen, H.J. Regional Radiation Results in Systemic Enhancement of Bone Marrow Metastases. Proc. 1991 Annual Meeting of the American Association for Cancer Research, 32:425, 1991.
  • Graves, B., Arguello, F., Duerst, R., Cohen, H.J. Systemic Intra- arterial Transplantation of Bone Marrow Cells as a Means for Faster and Sustained Engraftment After Lethal Doses of Radiation, JURMC 3:37(abst.), 1991.
  • Arguello, F., Baggs, R.B., Ryan, D., Liscano, J.C., Cohen, H.J., Frantz, C.N. Disseminated Human Lymphoblastic Leukemias (ALL) in Unconditioned Nude Mice. Blood, 82:10(998), 1994.
  • Arguello, F., Borch, R.F., Rayan, D., Liscano, J.C., Duerst, R.E., Cohen, H.J. Two Serologic Methods to Monitor the Engraftment, Growth and Treatment Response of Human Leukemias in SCID Mice. Blood, 82:10(999), 1994.
  • Shoemaker, R.H., Arguello, F., Alexander, M.R., Pittman, A.F., Boyd, M.R. Disseminated Growth of Human Melanoma Cell Lines Following Intracardiac Injection in Athymic and SCID Mice. Proc. 1995 Annual Meeting of the American Association for Cancer Research, 70(416), 1995.
  • Greene, J.F., Alexander, M.A., Arguello, F. Diphtheria Toxin- mediated Differentiation in Human Melanoma Xenografts. 1997 Annual Meeting of the International Academy of Pathology, Orlando, FL, March 1997.